Nordic Laboratories Holo DNA

Holo DNA is based on the famous DNA Core genetic analysis, developed by Nordic Laboratories. Download the full sample report here.

Holo DNA is a genetic test that explores how your genes interact with your environment. The report provides clear, practical recommendations across four areas:

• Key biological processes: methylation, detoxification, lipid metabolism
• Nutrient requirements: macro- and micronutrient response
• Weight management: risk markers and eating behaviour
• Exercise: power, endurance, recovery potential

Biomarkers Measured

Holo DNA analyses 79 genetic biomarkers across key biological systems. Each marker provides insights into metabolism, nutrient processing, exercise response, detoxification, inflammation, and other pathways, giving a comprehensive view of how your body responds to lifestyle and environmental factors.

Lipid Metabolism

• APOC3: Cholesterol metabolism
• APOE: Triglyceride-rich lipoprotein catabolism, antioxidant requirement
• CETP: HDL metabolism, lipid exchange between lipoproteins
• LPL: Hydrolyses triglycerides into free fatty acids
• PON1: Cardioprotective effect of HDL

Insulin Sensitivity

• PPARG: Adipocyte differentiation, glucose and lipid metabolism
• TCF7L2: Blood glucose homeostasis, insulin secretion and resistance
• SLC2A2: Glucose-induced insulin secretion
• FTO: Obesity susceptibility, type 2 diabetes risk
• IRS1: Insulin signal transmission

Methylation

• MTHFD1: Folate-dependent methylation pathway
• MTHFR: DNA synthesis vs. homocysteine remethylation
• MTR: Homocysteine → methionine conversion
• MTRR: Methylcobalamin regeneration
• CBS: Homocysteine removal from methionine cycle
• COMT: Methyl transfer to catecholamines

Detoxification

• CYP1A1: Environmental pro-carcinogen metabolism
• CYP1A2: Caffeine metabolism
• GSTM1 & GSTP1: Xenobiotic and oxidative stress removal
• GSTT1: Glutathione conjugation
• NQO1: Detoxification of quinones

Antioxidant Enzymes

• eNOS: Vascular tone and resistance
• MnSOD/SOD2: Antioxidant activity in mitochondria
• GPx: Selenium-dependent antioxidant enzyme
• CAT: Hydrogen peroxide conversion

Inflammation

• CRP: Inflammation marker
• IL-1A, IL-1B & IL-1RN: Inflammatory cascade regulation
• IL-6 & IL-6R: C-reactive protein expression
• TNFA: Proinflammatory cytokine

Other Pathways

• VDR, CYP2R1, GC: Vitamin D metabolism and bone health
• BC01: Vitamin A metabolism
• FUT2: Vitamin B12 absorption
• MCM6: Lactase persistence
• HLA DQ2/DQ8: Coeliac predisposition
• ALDH2: Alcohol metabolism
• HFE: Hemochromatosis predisposition
• ADIPOQ, APOA2, APOA5, FABP2, PLIN: Fat absorption and metabolism
• FADS1: PUFA metabolism
• UCP1, UCP2, UCP3: Energy production
• ADRB2, ADRB3: Energy mobilisation
• DRD2: Dopamine receptor, eating behaviour
• TAS1R2, TAS2R38: Taste sensitivity
• MCR4: Obesity candidate gene
• CLOCK: Circadian rhythm regulation
• AGT, ACE, BDKRB2, VEGF: Blood flow and vascular response
• NRF-2, PPARGC1A, PPARA: Energy and exercise response
• TRHR: TSH release stimulation
• ACTN3: Fast-twitch muscle fibre function
• AMPD1: Muscle fatigue and cramping
• COL1A1, COL5A1, GDF5: Collagen production, skeletal health

Sample & Processing

• Sample type: BloodSpot
• Processing time: 1-2 weeks

Privacy

DNA and original sample material are destroyed after 3 months. Only the specific SNPs in this test are analysed. No additional research is performed without your consent. Results are never sold or shared with third parties.

What You Receive

• Detailed report on your genetic profile
• Summarised recommendations based on findings
• Guidance across nutrition, lifestyle, and exercise
• Download the full sample report here.

Nordic Laboratories, at-home finger-prick blood analyses, with results prepared at the Helsinki Vallila laboratory in approximately 1-2 weeks.